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Rules Card Icon For corresponding page on Binding of Isaac: Rebirth Wiki, see Bosses .

Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Upon defeat, most bosses will drop an item from the boss item pool.

Bosses[ | ]

Name Portrait Health Description ID.Variant.SubType Location Mod
Fallen Soul
83495
500 apeares randomly after killing a boss 83495.0.0 N/A
The Peeping
Boss The Peeping The Peeping portrait
550 +{{{stage hp}}} Protected by some little buddies, the peeping uses a variety of blood barrages to attack isaac. 500.9900.0 N/A The Peeping
Moira
Boss The Ritual Moira portrait
3000 +150 Fights using eyeballs. 777.0.0 N/A The Ritual
PeePeeDie
Boss The Ritual PeePeeDie portrait
2500 +200 An invulnerable boss with only one weak spot. 780.0.0 N/A The Ritual
Puck
Boss Lunatic Mod Puck portrait
500 +30 Fights with magic runes that change how the player fights. 608.0.10 N/A Lunatic Mod
Souleater 2000 +{{{stage hp}}} Attacks the player using deadly blood lasers, and tricky projectile patterns. 800.125.0 N/A Godmode: Unleashed
Serpent
Boss Genesis Serpent portrait
? +{{{stage hp}}} Shoots the player along some platforms. {{{id}}}.1.1 N/A Genesis+
Honeydrop
Boss Devil's Harvest Honeydrop portrait
110 +{{{stage hp}}} A queen bee who attacks using shockwaves and by spawning flies to fight for him. 67.3.0 N/A Devil's Harvest
Technopin
Boss Devil's Harvest Technopin portrait
100 +{{{stage hp}}} An early boss that attacks by firing a laser towards isaac, and by leaping towards him. 62.0.10 N/A Devil's Harvest
Cacamancer
Boss Devil's Harvest Cacamancer portrait
300 +{{{stage hp}}} A large boss that fights by summoning poopy friends. 699.0.0 N/A Devil's Harvest
Mega Blister
Boss Devil's Harvest Mega Blister portrait
300 +{{{stage hp}}} A large blister that summons not one, not three, but TWO little balls as part of their attack! 303.0.5 N/A Devil's Harvest
Mega Portal
Boss Devil's Harvest Mega Portal portrait
200 +5 A big portal that summons other bosses to fight for them. 697.0.0 N/A Devil's Harvest
Primordial Monstro
Boss Devil's Harvest Primordial Monstro portrait
250 +{{{stage hp}}} This old Monstro protect himself with Ministros. 20.415.0 N/A Devil's Harvest
Mahalath
Boss Devil's Harvest Mahalath portrait
477 +{{{stage hp}}} A demonic boss that fights using their vomit. 777.0.0 N/A Devil's Harvest

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