 For corresponding page on Binding of Isaac: Rebirth Wiki, see Challenges .
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Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult.
 Bosses |
 Challenges |
 Chapters |
 Characters |
 Curses/Blessings |
 Items |
 Monsters
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 Objects |
 Pickups |
 Pocket Items |
 Rooms |
 Transformations |
 Trinkets |
 Unlockables
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 Mods |
 Teams
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