Challenges

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Pickup Rules Card icon.png For corresponding page on Binding of Isaac: Rebirth Wiki, see Challenges .

Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult.

Collectible Scissors icon.png The Modding of Isaac Collectible Scissors icon.png

MainPageModdedBosses.png Bosses MainPageChallenges.png Challenges MainPageModdedChapters.png Chapters MainPageModdedCharacters.png Characters Questionmarkisaac.png Curses/Blessings MainPageModdedItems.png Items MainPageModdedMonsters.png Monsters
MainPageModdedObjects.png Objects MainPageModdedPickups.png Pickups MainPageModdedPocketItems.png Pocket Items MainPageModdedRooms.png Rooms MainPageModdedTransformations.png Transformations MainPageModdedTrinkets.png Trinkets MainPageModdedUnlocks.png Unlockables
Collectible Dataminer icon.png Mods Round Worm Trio Monster.png Teams