The Modding of Isaac Wiki
Pickup Rules Card icon.png For corresponding page on Binding of Isaac: Rebirth Wiki, see Bosses .

Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Upon defeat, most bosses will drop an item from the boss item pool.


Name Portrait Health Description ID.Variant.SubType Location Mod
The Peeping
Boss The Peeping The Peeping portrait.png
550 Protected by some little buddies, the peeping uses a variety of blood barrages to attack isaac. 500.9900.0 N/A The Peeping
Moira 3000 +150 Fights using eyeballs. 777.0.0 N/A The Ritual
Boss The Ritual PeePeeDie portrait.png
2500 +200 An invulnerable boss with only one weak spot. 780.0.0 N/A The Ritual
Puck 500 +30 Fights with magic runes that change how the player fights. 608.0.10 N/A Lunatic Mod
Souleater 2000 Attacks the player using deadly blood lasers, and tricky projectile patterns. 800.125.0 N/A Godmode: Unleashed
Boss Genesis Serpent portrait.png
Shoots the player along some platforms. .1.1 N/A Genesis+
Boss Devil's Harvest Honeydrop portrait.png
110 A queen bee who attacks using shockwaves and by spawning flies to fight for him. 67.3.0 N/A Devil's Harvest
Boss Devil's Harvest Technopin portrait.png
100 An early boss that attacks by firing a laser towards isaac, and by leaping towards him. 62.0.10 N/A Devil's Harvest
Boss Devil's Harvest Cacamancer portrait.png
300 A large boss that fights by summoning poopy friends. 699.0.0 N/A Devil's Harvest
Mega Blister
Boss Devil's Harvest Mega Blister portrait.png
300 A large blister that summons not one, not three, but TWO little balls as part of their attack! 303.0.5 N/A Devil's Harvest
Mega Portal
Boss Devil's Harvest Mega Portal portrait.png
200 +5 A big portal that summons other bosses to fight for them. 697.0.0 N/A Devil's Harvest
Primordial Monstro 250 This old Monstro protect himself with Ministros. 20.415.0 N/A Devil's Harvest
Boss Devil's Harvest Mahalath portrait.png
477 A demonic boss that fights using their vomit. 777.0.0 N/A Devil's Harvest

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MainPageModdedBosses.png Bosses MainPageChallenges.png Challenges MainPageModdedChapters.png Chapters MainPageModdedCharacters.png Characters Questionmarkisaac.png Curses/Blessings MainPageModdedItems.png Items MainPageModdedMonsters.png Monsters
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